Daytime impairment can negatively influence an individual’s quality of life in different manners. Insomnia, characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning (American Academy of Sleep Medicine 2014), chronically affects approximately 5–20% of the adult population (Roth et al. Some unique features of daridorexant will be highlighted, such as the promotion of natural and surmountable sleep, the preservation of memory and cognition, the absence of tolerance development or risk of physical dependence, and how it can benefit daytime functioning. Here, we review the general pharmacology of daridorexant, based on nonclinical pharmacology studies of daridorexant, unpublished or already described, or based on work with other DORAs. This mechanism avoids a more widespread inhibition of neuronal pathways and associated side effects that are intrinsic to positive allosteric GABA-A receptor modulators. By specific binding to both orexin receptors, daridorexant inhibits the actions of the wake-promoting orexin (also called hypocretin) neuropeptides.
![memory note for pharmacology memory note for pharmacology](https://i.pinimg.com/736x/8c/13/84/8c13847702bd71f0b1ec3e0883b6a9da.jpg)
Daridorexant was discovered through a tailored research program aimed at identifying an optimized sleep-promoting molecule with pharmacokinetic properties appropriate for covering the whole night while avoiding next-morning residual activity at efficacious doses. Daridorexant is a new DORA that exhibited in phase 3 trials in insomnia not only a beneficial effect on sleep variables, measured objectively and assessed subjectively, but also an improvement in daytime functioning. NEW coverage highlights contemporary and timely topics on pharmacology — all in one clinical tool.Dual orexin receptor antagonists (DORAs) represent a novel type of sleep medication that provide an alternative to the traditionally used positive allosteric gamma-aminobutyric acid (GABA)-A receptor modulators. Colored highlights in the What You Need to Know sections emphasize four central topics: Serious/Life-Threatening Implications in pink Most Frequent Side Effects are blue Important Nursing Implications are yellow Patient Teaching information is green NEW! 8 brand-new cards focus on antiemetics, sunscreens, prostaglandins, acetaminophen, and more. What You Need to Know sections on each card cover key information in a quick and easy-to-review format. Colored thumb tabs at the bottom of the page allow you to find topics quickly.
#Memory note for pharmacology portable#
Thick pages and a spiral-bound format create a portable tool that is durable enough for the clinical environment. UNIQUE! Mnemonics and other time-tested memory aids help you grasp and remember even the most complex concepts.
![memory note for pharmacology memory note for pharmacology](https://cdn.shopify.com/s/files/1/2065/0707/files/cup-of-chamomile-tea-PM3DVH2_1024x1024.jpg)
UNIQUE! Color-highlighted monographs make it easier to identify nursing priorities on common medications. It makes studying pharmacology a memorable experience! UNIQUE! Over 90 full-color cartoons offer humorous and memorable presentations of key drugs. Created by nursing educators JoAnn Zerwekh and Jo Carol Claborn, this unique tool may be used as either a spiral-bound notebook or as individual flashcards. These durable, portable cards use mnemonics and other time-tested learning aids to help you prepare for class, clinicals, and the NCLEX® examination. Use this set of colorful cards to master pharmacology! With over 90 cartoons covering drugs and related topics, Mosby's Pharmacology Memory NoteCards: Visual, Mnemonic, and Memory Aids for Nurses, 4th Edition uses humor and illustrations to make studying easier and more fun.